This is a new generation of innovative, environmentally safe, prolonged-action medications that eliminate the risk of gastrointestinal ulcers and environmental pollution with microplastics
Each of us has taken ibuprofen or ketorolac. But let's look at the scale of the problem: more than 30 million people worldwide take these medications every day. This problem is especially acute for palliative care patients, military personnel with injuries and wounds, and athletes with chronic injuries, for whom pain control can be long-term and require regular pharmacotherapy. Due to their short-lived effect, patients are forced to take them 3–4 times a day, which literally destroys the stomach. Our Cost Minimisation Analysis proved that switching to a single GreenMed capsule eliminates these toxic peaks and saves the patient money. The environmental consequences are no less alarming. According to UN and PNAS data, drug residues are detected in 100% of wastewater samples, and a quarter of the planet's rivers are already poisoned with a critical concentration of analgesics. Traditional shells take years to break down into microplastics. The world urgently needs "Green Pharmacy." Our solution is GreenMed: EcoPills. This is a new-generation capsule based on evidence-based active pharmaceutical ingredients — ibuprofen and ketorolac tromethamine. Thanks to our development, a patient only needs to take one capsule a day instead of four. The drug is released gently and evenly, without irritating the stomach. And after use, the eco-packaging and shell components fully and safely decompose in the environment. GreenMed: EcoPills — one capsule, longer action, less waste.
GreenMed: EcoPills — when science is enough to heal without harm
— Злата ТимощукFumed silica is a multifunctional excipient with unique physicochemical properties, making it indispensable in the development and production of various pharmaceutical preparations. Research continues to expand the range of applications of this valuable material in pharmacy, particularly for creating drugs with prolonged pharmacological action. As anti-inflammatory non-steroidal drugs, we used common ones such as ibuprofen – a non-steroidal anti-inflammatory drug that acts directly against pain, fever, and inflammation. And ketorolac tromethamine, which belongs to the group of non-steroidal anti-inflammatory drugs and has analgesic, anti-inflammatory, and antipyretic effects. For ketorolac, a real breakthrough was hydrophobic silica AM-1-300, which, due to the slow penetration of water into the pores, extended the drug retention time to 9 hours. In the case of ibuprofen, the best result was shown by a composite based on A-300-NH2: thanks to strong electrostatic interaction and hydrogen bonds, after 24 hours only 81% of the substance had passed into solution.
The IR spectrum of the pristine A-300 silica contains Si–O–Si bands (~1100 and ~800 cm⁻¹) and hydroxyl group bands (~3400, ~1630 cm⁻¹). The spectrum of the modified sample confirms the grafting of 3-aminopropyltriethoxysilane by the appearance of bands of C–H bonds of alkyl radicals and N–H bonds
Silochrome accelerates the release of ibuprofen compared to the tablet form. Other types of nanosilicas used (A-300, AM-1-300, A-300-NH2) slow down this process.
Release from the tablet is multistage: within 10–20 minutes, 30–60% of the substance is released, within 30 minutes — ~80% (pharmacopoeial standard), and by the 70th minute 98% is reached.
The composite based on A-300 has a stepwise release profile: within 10 minutes ~37% of ibuprofen is leached
It has been proven that pyrogenic nanodispersed silicas A-300, Silochrom, AM-1-300 and A-300-NH2 can be used for impregnating ibuprofen and ketorolac tromethamine onto their surface.
Composites of ibuprofen and ketorolac tromethamine based on A-300, Silochrom, AM-1-300 and A-300-NH2 silicas
The evaluation of the completeness of desorption of the studied substances from silica-based modified composites was carried out by quantitatively determining the content of ibuprofen and ketorolac tromethamine in the desorbed solutions.
To study the adsorption properties of pyrogenic nanodispersed silica, samples of its four forms were used:
A-300 hydrophilic surface 300 m2/g
A-300-NH2 hydrophilic surface 300 m2/g
Silochrome hydrophilic surface 114 m2/g
AM-1-300 hydrophobic surface 300 m2/g
Research stages:
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Grade 10
Kyiv
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